Hexosamine Metabolism
نویسندگان
چکیده
منابع مشابه
Acute Regulation of Cardiac Metabolism by the Hexosamine Biosynthesis Pathway and Protein O-GlcNAcylation
OBJECTIVE The hexosamine biosynthesis pathway (HBP) flux and protein O-linked N-acetyl-glucosamine (O-GlcNAc) levels have been implicated in mediating the adverse effects of diabetes in the cardiovascular system. Activation of these pathways with glucosamine has been shown to mimic some of the diabetes-induced functional and structural changes in the heart; however, the effect on cardiac metabo...
متن کاملHexosamine Biosynthesis Is a Possible Mechanism Underlying Hypoxia’s Effects on Lipid Metabolism in Human Adipocytes
INTRODUCTION Hypoxia regulates adipocyte metabolism. Hexosamine biosynthesis is implicated in murine 3T3L1 adipocyte differentiation and is a possible underlying mechanism for hypoxia's effects on adipocyte metabolism. METHODS Lipid metabolism was studied in human visceral and subcutaneous adipocytes in in vitro hypoxic culture with adipophilic staining, glycerol release, and palmitate oxidat...
متن کاملThe hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism.
Glucose and glutamine serve as the two primary carbon sources in proliferating cells, and uptake of both nutrients is directed by growth factor signaling. Although either glucose or glutamine can potentially support mitochondrial tricarboxylic acid (TCA) cycle integrity and ATP production, we found that glucose deprivation led to a marked reduction in glutamine uptake and progressive cellular a...
متن کاملHexosamine biosynthesis pathway ( HBP )
27 There is increasing evidence that endoplasmic reticulum (ER) stress contributes to the 28 development atherosclerosis in diabetes mellitus. The purpose of this study was to determine the effects 29 of increased hexosamine biosynthesis pathway (HBP) flux on ER stress levels and the complications of 30 ER stress associated with diabetes and atherosclerosis in hepatic cells. Glutamine:fructose-...
متن کاملThe Synthesis of Hexosamine in Tumor Homogenates
Leloir a n d Cardini (17) described the essential react ions leading to the enzymat i c product ion of g h c o s a m i n e . Using ex t rac t s f rom N e u r o s p o r a erassa, t hey repor t ed t h a t g lucosamine-6-phosphate was synthes ized f rom hexose-6-phosphate and glutamine . Subsequen t research by these and o the r inves t iga tors d e m o n s t r a t e d glucosamine synthesis in pig...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1964
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(20)82250-9